Lab introduction
The Shin group uses chemical biological tools to elucidate and modulate biological systems.
Foldamer design to mimic secondary structures of biomolecules

Protein-protein interactions (PPIs) that regulate a variety of cellular processes occur at helical interfaces, and modulation of them could have therapeutic benefits. We are interested in the development of strategies for the helical
peptidomimetics
design incorporated with non-natural amino acids such as
b
- and
g
-residues, which increase the resistance of the peptide to proteolytic degradation compared to the
a
-analogues. We are developing novel non-natural amino acids, and studying secondary structures of the peptides containing those residues to apply them for various purposes.
Applications of peptidomimetics

We are interested in applications of
peptidomimetics
in various fields including therapeutics via modulation of protein-protein interactions, anti-biotic peptides, anti-biofilm,
nano
-biosensors, etc.
Peptide library construction

Peptide-based materials exhibit high efficiency and specificity in biological systems but have critical limitations such as low cell permeability and low resistance to proteolytic digestion. To overcome those limitations in peptide library screening, we are developing peptide gene libraries to express in engineered cells to screen those peptides for specific activities in cells.
Non-canonical translation regulation
Regulation of non-canonical translation processes could be useful to address certain types of neurodegenerative diseases, cancer, and viral diseases. We are developing cell screening systems to monitor those non-canonical translation processes and aim to discover factors to develop useful agents.
Group Leader
Young Hee Shin Ph.D.
- Laboratory: Room 306, Building D, Tech University of Korea
- Tel: 031-8041-0616
-
e-mail: yshin@tukorea.ac.kr
-
Home page: https://sites.google.com/tukorea.ac.kr/yshin-lab/home