About NBME LAB
Our vision is to develop new technologies to treat and diagnose intractable diseases through a better understanding of chemistry, biology, pharmacy, and medicine. To achieve this goal, our team leverages deep expertise in drug delivery, nanomedicine, biomedicine, nanotechnology, biotechnology, polymers, and cellular engineering to develop robust engineering solutions.

Nanomedicine
Our laboratory focuses on drug delivery systems, photodynamic therapy, and ultrasound dynamic therapy for the treatment of various intractable diseases by applying nanomedicine technology.

Nanomedicine Research
- Stimuli-responsive nanomedicine
- Immunotherapeutic nanomedicine
- Biopolymer

Biomedicine
We are developing biopharmaceuticals based on extracellular vesicles for the treatment of various intractable diseases.

Biomedicine Research
- Stem cell-derived extracellular vesicles
- Immune cell-derived extracellular vesicles
- Engineering strategies for extracellular vesicles

Diagnostic platform
Our laboratory focuses on novel nano/biotechnology to develop a diagnostic platform (e.g., ultrasound contrast agent, MRI contrast agent, and liquid biopsy system) to enable early diagnosis of various incurable diseases.

About PI
Assistant Professor : Dong Gil You, Ph.D.
Office : D404, 237 Sangidaehak-ro, Siheung-si, Gyeonggi-do
Tel :031-8041-0613
Selected Publications (from over 50 papers)
- Kim CH*, You DG*, Pramod Kumar EK, Han KH, Um W, Lee J, Lee JA, Jung JM, Kang H, Park JH. Self-immolative nanosensitizer for glutathione depletion-assisted sonodynamic therapy.
Theranostics 2022;12:17:7465-7475. - You DG*, An JY*, Um W, Jung JM, Oh BH, Nguyen VQ, Jeon J, Lee J, Jo DG, Cho YW, Park JH. Stem cell-derived extracellular vesicle-bearing dermal filler ameliorates the dermis microenvironment by supporting CD301b-expressing macrophages. ACS Nano 2022;16:1:251-260.
- You DG*, Oh BH*, Nguyen VQ, Lim GT, Um W, Jung JM, Choi JS, Choi YC, Jung YJ, Lee J, Jo DG, Cho YW, Park JH. Vitamin A-coupled stem cell-derived extracellular vesicles regulate the fibrotic cascade by targeting activated hepatic stellate cells in vivo. Journal of Controlled Release 2021;336:10:285-295.
- You DG*, Lim GT*, Kwon S, Um W, Oh BH, Song SH, Lee J, Jo DG, Cho, YW, Park JH. Metabolically engineered stem cell–derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis. Science Advances 2021;7:eabe0083 (highlighted in Nat. Rev. Rheumatol.).
- Lim GT*, You DG*, Han HS, Lee H, Shin S, Oh BH, Kumar EKP, Um W, Kim CH, Han S, Lee S, Lim S, Yoon HY, Kim K, Kwon IC, Jo DG, Cho YW, Park JH. Bioorthogonally surface-edited extracellular vesicles based on metabolic glycoengineering for CD44-mediated targeting of inflammatory diseases. Journal of Extracellular Vesicles 2021;10:e12077.
- Jeon J*, You DG*, Um W, Lee J, Kim CH, Shin S, Kwon S, Park JH. Chemiluninescence resonance energy transfer-based nanoparticles for quantum yield-enhanced cancer phototheranostics. Science Advances 2020;6:eaaz8400 (PMID: 32637587).